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While insulin and leptin may act as long-term regulators of energy balance, they appear to have little role in the initiation of a meal The biological signals that are responsible for this are still little understood In rodents, there is a small drop in blood glucose just prior to a meal If feeding does not occur immediately, blood glucose returns to normal and a meal will occur after the next spontaneous fall in glucose If such a decrease is produced experimentally, the animal will feed, but if the fall in glucose is prevented, feeding still continues as normal (Camp eld & Smith, 1990) The signals generated to limit a meal size have been much more extensively investigated In addition to the neural signals from the stomach, duodenum and the liver, a number of peptides are secreted from the gastrointestinal tract.

Prior to 1975, parents often were not included in special education placement decisions, and school policies of closed records made it difficult for parents to gain access to information about how such decisions were made IDEA 1997 clarified that each SEA or LEA must ensure that the parents of a child with a disability are members of any group that makes decisions on the identification, evaluation, and educational placement of their child (34 CF R 300501) In order to ensure parent participation and shared decision making in the development of the IEP, IDEA-Part B requires the school to provide adequate prior notice of team meetings, and the meeting must be scheduled at a mutually agreed upon time and place Notice must include the purpose, time, place, and location of the meeting and who will be in attendance.

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Levels of lead and zinc in water and sediment were found to be considerably higher in Bayou Trepagnier than in a nearby control stream, and tissue metal levels of mosquito sh were highly elevated for lead and to a lesser extent, zinc Fish collected from Bayou Trepagnier and exposed to zinc in a 96 hour laboratory bioassay were found not to differ in their sensitivity to zinc from conspeci cs collected from a control site In contrast, Bayou Trepagnier sh were found to exhibit an increased resistance to lead, although this difference to lead between Bayou Trepagnier sh and control sh was no longer evident when both groups of sh were kept for 34 days under identical clean water conditions in the laboratory.

A meeting does not include informal or unscheduled conversations among school personnel or conversations on issues such as teaching methodology, lesson plans, or coordination of services if those issues are not addressed in the IEP A meeting also does not include preparatory activities that school personnel engage in to develop a proposal (or a response to a parent proposal) that will be discussed at a later meeting Schools must make reasonable efforts to ensure that parents understand, and are able to participate, in any group discussions relating to the educational placement of their child, including providing interpreters for parents who are deaf or whose native language is other than English If neither parent can attend, the school must attempt to ensure parent participation using other means such as conference telephone calls (34 CFR 300501).

Stomach stretch receptor activation is important in limiting food intake but if the stomach size remains constant due to the presence of a stula, feeding still ceases This effect may be mediated by peptides released from the gastrointestinal tract to suppress feeding, and one of these is the duodenal peptide, cholecystokinin (CCK) (Houpt, 1982) CCK activates CCK-A receptors on small unmyelinated vagal afferents which project to the brain stem (Reidelberger, 1994) Administration of CCK into the peritoneal cavity reduces food intake (Batt, 1983) and this action is abolished by vagotomy (Reidelberger, 1992) Rodents lacking CCK-A receptors are obese and do not respond to exogenous CCK (Takiguchi et al, 1997) Similarly, chronic administration of CCK antagonists also results in obesity (Meereis et al, 1998) CCK acts synergistically with leptin.

Klerks and Lentz (1998) concluded that although a genetic basis of the difference in resistance between the two populations cannot be fully excluded, it appears that the elevated lead resistance in Bayou Trepagnier mosquito sh is due to acclimation (physiological, individually-based) rather than adaptation at the population level Similarly, Klerks et al (1997) examined physiological acclimation, genetic adaptation and genetic differentiation in darter gobies (Gobionellus boleosoma) inhabiting a coastal marsh with a long history of PAH contamination No acclimation was detected and a two week pre-exposure at the polluted site resulted in a decreased rather than an increased resistance in a subsequent laboratory exposure to polluted sediment Additionally, sh collected from sites with elevated sediment PAH levels did not exhibit an increased resistance in bioassays with polluted sediment, con rming the lack of acclimation and indicating a lack of adaptation to the pollutants Klerks et al.

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