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The kidneys receive an enormous blood flow: more than 1 L/min, or about 20% of the cardiac output This blood flow is far in excess of the kidney s metabolic need and provides the kidneys with the flexibility to alter their blood flow in response to physiological demand All of this blood flows through glomeruli in the cortex1 The vast majority continues on (via efferent arterioles) to peritubular capillaries in the cortex and then into the renal venous system A much smaller fraction, about 5 10%, flows from efferent arterioles down into the medulla This medullary blood derives from juxtamedullary glomeruli that are situated near the corticomedullary border Consider some typical numbers A normal hematocrit is 045, ie, 45% of the blood volume is composed of red blood cells and the remaining 55% is almost entirely plasma Typical renal blood flow (RBF) is 11 L/min The renal plasma flow (RPF) 5 055 11 L/min 5 605 mL/min As stated in 1, a typical glomerular filtration rate (GFR) is about 125 mL/min Thus, of the 605 mL of plasma that enters the glomeruli via the afferent arterioles, 125 mL, or 20%, filters into Bowman s space The remaining 480 mL passes via the efferent arterioles into the peritubular capillaries This ratio GFR/RPF is known as the filtration fraction Because freely filtered substances are passing into Bowman s space along with the water, about 20% of all freely filtered substances (eg, sodium) that enter the kidney also move into Bowman s space

Kinetic Molecular Theory 2 The correct answer option Obviously, this is the one selection that best completes the statement, or responds to the question in the stem Because you have purchased this book, you will select this option many, many times 3 Distracter options Just as it sounds, these are the incorrect answers intended to distract anyone who decided not to purchase this book You can locate this person in the exam room by searching for the individual who is repeatedly smacking his or her forehead on the desktop Students who do well on multiple-choice exams are so well prepared that they can easily find the correct answer, but other students do well because they are perceptive enough to identify and avoid the distracters Much research has been done on how best to study for, and complete, multiple-choice questions You can find some of this research by using your favorite Internet search engine, but here are a few tips that many chemistry students find useful 1 Let s be careful out there You must carefully read the question This sounds obvious, but you would be surprised how tricky those test developers can be For example, rushing past, and failing to see, the use of a negative, can throw a student

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The basic equation for blood flow through any organ is as follows: Q 5 P/R, where Q is organ blood flow, P is mean pressure in the artery supplying the organ minus mean pressure in the vein draining that organ, and R is the total vascular resistance in that organ Resistance is determined by the blood viscosity and the lengths and radii of the organ s blood vessels, the arteriolar radii being overwhelmingly the major contributor As described by Poiseiulle s law, resistance of a cylindrical vessel varies inversely with the fourth power of vessel radius It takes only a 19% decrease or increase in vessel radius to double or halve vessel resistance The radii of arterioles are regulated by the state of contraction of the arteriolar smooth muscle The presence of 2 two sets of arterioles (afferent and efferent) and 2 sets of capillaries (glomerular and peritubular) makes the vasculature of the cortex unusual (The vasculature of the medulla is even more unusual, but we concentrate on the cortex for now) Normally, the resistances of the afferent and efferent arterioles are approximately equal and account for most of the total renal vascular resistance Resistance in arteries preceding afferent arterioles (ie, cortical radial arteries) plays some role also, but we concentrate on the arterioles Vascular pressures (ie,

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They are nonmetals They forms monatomic anions with a 1 charge In their standard states they may exist as solids, liquids, or gases All may adopt positive oxidation states They are next to the noble gases on the periodic table

There is some evidence that a small fraction of blood approaching Bowman s capsule in afferent arterioles is diverted directly to the medulla without going through glomeruli This fraction, if it exists at all, is small

Table 6 1 is a balance sheet for sodium chloride Clearly, the major route of salt excretion from the body under normal circumstances is via the kidneys The large amount excreted should not obscure the fact that nearly all the filtered sodium

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