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personal space as a result of damage to one (the dominant) hemisphere More recent observations indicate that patients with right parietal lesions show variable but lesser elements of ipsilateral neglect in addition to the striking degree of contralateral neglect, suggesting that, in respect to spatial attention, the right parietal lobe is truly dominant (Weintraub and Mesulam) A clever observation of Bisiach and Luzzatti has suggested that the loss of attention to one side of the environment extends to the mental representation of space Their patient with a right parietal lesion was asked to describe from memory the buildings lining the Piazza del Duomo, rst as if seen from one corner of the piazza and then from the opposite corner In each instance the description omitted the left side of the piazza from the observer s perspective This has similarities to the topographagnosia described further on Perhaps another aspect of parietal lobe physiology, revealed by human disease, is the loss of exploratory and orienting behavior with the contralateral arm and even a tendency to avoid tactile stimuli Mori and Yamadori call this rejection behavior DennyBrown and Chambers attribute the released grasping and exploring that follow frontal lobe lesions to a disinhibition of inherent parietal lobe automatisms, but we have no way of con rming this It is of interest that demented patients with prominent grasp re exes tend not to grasp parts of their own bodies unless there has been a parietal lesion, in which case there may be self-grasping of the forearm opposite the lesion (Ropper) Conventional treatments for hemispatial neglect use prismatic glasses and training in visual exploration of the left side Of some interest has been an approach that demonstrates improvement by the application of vibratory stimulation to the right side of the neck as reported by Karnath and colleagues or of the ipsilateral labyrinth by caloric or electrical means (a similar treatment has been successful in some cases of dystonic torticollis, see Chap 6) Gerstmann Syndrome This syndrome provides the most striking example of what might be viewed as a bilateral asomatognosia and is due to a left or dominant parietal lesion The characteristic features are inability to designate or name the different ngers of the two hands ( nger agnosia), confusion of the right and left sides of the body, and inability to calculate (dyscalculia) and to write (dysgraphia) One or more of these manifestations may be associated with word-blindness (alexia) and homonymous hemianopia or a lower quadrantanopia, of which the patient is usually unaware The lesion is in the inferior parietal lobule (below the interparietal sulcus), particularly the angular gyrus or subjacent white matter of the left hemisphere There has been a dispute as to whether the four main elements of the Gerstmann syndrome have a common basis or only an association Benton states that they occur together in a parietal lesion no more often than do constructional apraxia, alexia, and loss of visual memory and that every combination of these symptoms and those of the Gerstmann syndrome occurs with equal frequency in parietal lobe disease Others, including the authors, tend to disagree and believe that right-left confusion, digital agnosia, agraphia, and acalculia have special signi cance, possibly being linked through a unitary defect in spatial orientation of ngers, body sides, and numbers The relationship between the ngers and the ability to enumerate is especially intriguing and relates to other arithmetic dif culties, discussed below Dyscalculia has attracted little critical attention, perhaps because it occurs most often as a by-product of aphasia and an inability of the patient to appreciate numerical language Primary.

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dyscalculia is usually associated with the other elements of the Gerstmann syndrome Computational dif culty may also be part of the more complex visuospatial abnormality of the nondominant parietal lobe; there is then dif culty in the placing of numbers in speci c spatial relationships while calculating In such cases, there is no dif culty in reading or writing the numbers or in describing the rules governing the calculation, but the computation cannot be accomplished correctly with pencil and paper Hecaen has made a distinction between this type of anarithmetia and dyscalculia; in the latter, the process of calculation alone has been disturbed; in the former, there is an inability to manipulate numbers and to appreciate their ordinal relationships Recognition and reproduction of numbers are intact in both An analysis of how computation goes awry in each individual case is therefore required Lesions of the superior parietal lobule may interfere with voluntary movement of the opposite limbs, particularly the arm, as pointed out by Holmes In reaching for a visually presented target in the contralateral visual eld and to a lesser extent in the ipsilateral eld, the movement is misdirected and dysmetric (the distance to the target is misjudged) This disorder of movement, mentioned above in the general discussion of parietal signs and sometimes referred to as optic ataxia, resembles cerebellar ataxia and may be explained by the fact that cortical areas 7 and 5 receive visual projections from the parastriate areas and proprioceptive ones from the cerebellum, both of which are integrated in the multimodal parietal cortex Areas 5 and 7, in turn, project to frontal areas 6, 8, and 9, where ocular scanning and reaching are coordinated Ideomotor and Ideational Apraxia As discussed extensively in Chap 3, patients with parietal lesions of the dominant hemisphere who exhibit no defects in motor or sensory function lose the ability to perform learned motor skills on command or by imitation They can no longer use common implements and tools, either in relation to their bodies (eg, brushing teeth, combing hair) or in relation to objects in the environment (eg, a doorknob or hammer) The patient holds the implement awkwardly or seems at a loss to begin the act It is as though the patient had forgotten the sequences of learned movements The effects are bilateral It is of interest that, in both agraphia and acalculia, the motor defect is intertwined with some of these agnosic defects; hence the term apractognosia seems appropriate for the combined problem From the above descriptions, it is evident that the left and right parietal lobes function differently The most obvious difference, of course, is that language and arithmetical functions are centered in the left hemisphere It is hardly surprising, therefore, that verbally mediated or verbally associated spatial and praxic functions are more affected with left-sided than with right-sided lesions It must also be realized that language function involves cross-modal connections and is central to all cognitive functions Hence cross-modal matching tasks (auditory-visual, visual-auditory, visual-tactile, tactile-visual, auditory-tactile, etc) are most clearly impaired with lesions of the dominant hemisphere Such patients can read and understand spoken words but cannot grasp the meaning of a sentence if it contains elements of relationship (eg, the mother s daughter versus the daughter s mother, the father s brother s son, Jane s complexion is lighter than Marjorie s but darker than her sister s ) There are similar dif culties with calculation, as just described The recognition and naming of parts of the body and the distinction of right from left and up from down are learned, verbally mediated spatial concepts that are disturbed by lesions in the dominant parietal lobe.

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