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This rare condition is the result of a toxin secreted by the gravid tick In Canada and the northwestern United States, the wood tick Dermacentor andersoni is mainly responsible; in the southeastern United States it is Dermacentor variabilis, a dog tick (the tick in Australia is the Ixodes holocyclus), but various other ticks may occasionally have the same effect The illness is more common and is generally more severe in cases on the Australian Continent than it is in North America Most cases occur in children because their small body mass renders them susceptible to the effects of relatively small amounts of the toxin The illness arises almost exclusively in the spring, when the mature gravid ticks are most plentiful Clinical manifestations require that the tick be attached to the skin for several days The neurotoxin causes a generalized, accid, are exic paralysis, appearing over 1 or 2 days thereby mimicking the GuillainBarre syndrome In a few cases, several days of ataxia and are exia precede the paralysis, but sensory loss tends to be minimal External ophthalmoplegia, which occurred in 5 of the 6 children described by Grattan-Smith et al, is exceptional judging by other reports; internal ophthalmoplegia and pharyngeal weakness are also known to occur, and while not typical, raise the possibility of botulism or diphtheria The CSF is normal and electrophysiologic studies show reduction in the amplitude of the muscle action potentials but normal or only slightly slowed nerve conduction Prominent ptosis and neck weakness may also raise the question of a neuromuscular process, but repetitive stimulation testing is normal or evokes only a slight decrement or increment in some cases The ticks tend to attach to the hairlines or in the matted hair of the scalp, neck, and pubis, where a careful search will reveal them (for which reason nurses and electroencephalography technicians often are most likely to nd them; see Felz et al) The diagnosis is much in the awareness of clinicians in endemic areas during the tick season, for they are grati ed with rapid and dramatic improvement when the tick is removed The paralysis is reported to become transiently worse after tick removal in some of the Australian cases From a neurologic point of view, the frequent disorder that follows tick bite is what has come to be known as Lyme disease so named for the Connecticut community in which it was discovered The causative agent is Borrelia burgdorferi, a spirochetal organism The disorder is discussed fully with other infectious diseases in Chap 32 and in Chap 46, with the neuropathies. free asp. net mvc pdf viewer How to create a PDF file in ASP . NET MVC - Syncfusion
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